TF and cancer: This relationship is a common feature of context-specific transcriptional addiction where TF dependency is often imposed by the developmentally programmed transcriptional state of the cancer cell of origin rather than being directly established by the tumor-initiating mutation(s) (Hnisz et al. 2015; Boeva et al. 2017; Bradner et al. 2017; Mack et al. 2017, 2019; van Groningen et al. 2017).