Acute leukemias carrying KMT2A (MLL) translocations represent ∼5%–10% of acute leukemia in all age groups and up to 70% of infantile leukemia (Krivtsov and Armstrong 2007; Balgobind et al. 2009; Bolouri et al. 2018; Chan and Chen 2019). Here, KMT2A is linked to acute leukemia.