APOE and early-onset autosomal dominant Alzheimer disease: In the studies that reported stratified results according to ApoE ε4 carrier status, the pooled RR between PA and all-cause dementia or Alzheimer’s disease was similar for ApoE ε4 carriers (RR 0.81, 95% CI 0.67 to 0.98) and non-carriers (RR 0.72, 95% CI 0.56 to 0.92).