For example, the TE of overweight/obesity on poor PF, expressed as an OR, was 1.66 (95% CI: 1.37, 2.01), with a direct effect of 1.46 (1.19, 1.78); the proportion of the total effect mediated by CRP was 26.12% (95% CI: 2.40, 49.84). The gene discussed is CRP; the disease is Obesity.