Broadly similar patterns of associations were observed when, (i) the exposure was overweight/obesity at 33y (Supplementary Table S3), (ii) we included individuals with CRP > 10 mg/l (n = 179) in the analysis (Supplementary Table S4) and (iii) we considered waist-hip ratio at 45y as an additional intermediary confounder (Supplementary Table S5). The gene discussed is CRP; the disease is Obesity.