Of particular relevance is the observed positive effect of resistance training on reducing CRP levels (Sardeli et al., 2018), which as a result of its additional beneficial effects on muscular strength and PF (Chodzko-Zajko et al., 2009, Csapo and Alegre, 2016), may represent a particularly efficacious means of tackling any obesity-induced reductions in subsequent PF. The gene discussed is CRP; the disease is obesity due to melanocortin 4 receptor deficiency.