Isotope-dilution PRM analysis of 50 HDL proteins demonstrated that AMBP, C4BPA, CST3, IGF1, and SFTPB differed in relative abundance between control subjects of a randomly selected cohort and subjects with incident CVD in CACTI, a prospective study of complications in patients with T1DM. This evidence concerns the gene SFTPB and type 1 diabetes mellitus.