In a Drosophila model of TRPV4 neuropathy (67), we also observed reduced ubiquitination of R269C TRPV4 as well as rescue of TRPV4 Ub levels in flies expressing R269C TRPV4 along with the pore-inactivating M680K mutation (Fig. 7, G and H). This evidence concerns the gene TRPV4 and neuropathy.