Overall, although any CYP2C19 LOF allele might affect the risk of MACEs (OR: 1.11; 95% CI: 0.76–1.64; P = 0.586) and stroke (OR: 1.71; 95% CI: 0.99–2.96; P = 0.054), whereas these associations without statistical significance. Here, CYP2C19 is linked to stroke disorder.