The largest effect sizes were observed in BNP (B-type natriuretic peptide; RR, 1.92 [95% CI, 1.70–2.18]) and NT-proBNP (N-terminal pro-BNP; RR, 1.85 [95% CI, 1.63–2.10]), 2 biomarkers that have been routinely used in the clinic to diagnose HF. This evidence concerns the gene NPPB and hydrops fetalis.