ITGB4 and cancer: Sung et al. uncovered an intriguing phenomenon that ITGB4-overexpressing TNBC cells transmitted ITGB4 proteins to cancer-associated fibroblasts (CAFs) in an exosome-independent way, thereby triggering BNIP3L-related mitochondrial autophagy and lactate production in CAFs (Sung et al., 2020).