TGM2 and CTGF have been shown to play a role in HTM cell pathobiology in glaucoma (Tovar-Vidales et al., 2008; Junglas et al., 2012); here we showed that mRNA of TGM2, CTGF and ANKRD1 were also significantly upregulated in GTM cells vs. normal HTM cells, whereas no significant difference was observed for CYR61 (Figure 1B; Supplementary Figures S2B,C). Here, CCN1 is linked to glaucoma.