The TM from POAG eyes is stiffer than that from healthy eyes (Last et al., 2011; Wang et al., 2017a; Vahabikashi et al., 2019); transforming growth factor beta 2 (TGFβ2), the predominant TGFβ isoform in the eye and aqueous humor, has been identified as a major contributor to the pathologic changes occurring in ocular hypertension and POAG (Granstein et al., 1990; Quigley, 1993; Inatani et al., 2001; Fuchshofer and Tamm, 2009; Agarwal et al., 2015; Kasetti et al., 2018). This evidence concerns the gene TGFB1 and open-angle glaucoma.