YAP1 and glaucoma: Here, we found that YAP/TAZ nuclear localization, the principal mechanism to regulate their function, is significantly higher in TM cells from patients with glaucoma compared to cells isolated from healthy tissue, exhibiting normal variability between cells from different donors (i.e., one GTM cell strain showed higher baseline YAP/TAZ nuclear localization and transcriptional activity compared to the other) (Figure 1; Supplementary Figures S2, S3).