It has been demonstrated that certain glaucoma related molecules that influence outflow function, such as dexamethasone, lysophosphatidic acid and interleukin-6, mediate the expression of YAP and TAZ in HTM cells (Ho et al., 2018; Honjo et al., 2018; Peng et al., 2018; Yemanyi and Raghunathan, 2020). The gene discussed is WWTR1; the disease is glaucoma.