It is intriguing that six (HGS, CEP131, MAFG, MAFG-DT, FOXK2, and SIRT7) of them have already been discovered as proto-oncogenes in HCC (Canal et al., 2015; Lin et al., 2017b; Liu et al., 2017; Liu et al., 2018c; Ouyang et al., 2019; Zhao et al., 2019). The gene discussed is HGS; the disease is hepatocellular carcinoma.