Unlike those of EZH2 (Gao et al., 2014; Liu et al., 2015; Zhuang et al., 2016; Chen et al., 2018b), the roles of EHMT2 and SMYD3 in mediating transcriptional regulation in carcinogenesis are still not fully characterized in HCC (Zhang et al., 2021a; Guo et al., 2021). This evidence concerns the gene EZH2 and hepatocellular carcinoma.