Immune factors, including cytokines (such as interleukin-11 (IL-11), and interleukin-6 (IL-6)) and chemokines (including IL-6, CCL5, and CXCL10), play a role in converting normal fibroblasts into CAFs, and some of these immune factors act in a feedback loop between the CAFs and the tumor (Yoshida, 2020). This evidence concerns the gene IL6 and neoplasm.