Nearly all epithelial cancers involve lost, reduced, or mixed expression of E-cadherin, and with that an assumed loss of cell-cell adhesion; however, it is also true that cohesive clusters of tumor cells are the greater source of metastases (Friedl and Gilmour, 2009; Aceto et al., 2015; Cheung and Ewald, 2016; Fang and Kang, 2021), as individual cells do not survive to seed distant sites (Harryman et al., 2016). The gene discussed is CDH1; the disease is neoplasm.