Erdogan et al., in working with the DU145 prostate cancer cell line, found that immunofluorescence (IF) staining of DU145-CAF co-cultures for N-cadherin and E-cadherin revealed DU145 cells forming E-cadherin junctions with other DU145 cancer cells, but the CAFs formed N-cadherin junctions with other CAFs—they did not observe any N-cadherin/E-cadherin connections at sites where DU145 cancer cells made contact with CAFs (Erdogan et al., 2017b). This evidence concerns the gene CDH2 and Familial prostate cancer.