CDH1 and neoplasm: Along with the decrease in E-cadherin expression in CRC noted above, an overexpression of both α6 and β4 integrin subunits occurs in the primary tumor as well as in established CRC cell lines, with the relocalization of α6β4 to the actin cytoskeleton, resulting in a more migratory and anoikis-resistant phenotype (Beaulieu, 2019).