The function of α7β1 integrin is to facilitate muscle cell interactions with laminin in the ECM, while the role of α6β1 integrin (also specific for laminin) is to mediate tumor cell–ECM interactions and smooth muscle invasion (Rubenstein et al., 2019; Harryman et al., 2021), suggesting that there may be integrin cooperation between the invading tumor and the normal muscle during laminin-based invasion (Harryman et al., 2021). This evidence concerns the gene LAMB2 and neoplasm.