Integrin clustering stimulates the recruitment of several focal adhesion proteins—including FAK, ILK (which appears to down-regulate E-cadherin (Canel et al., 2013) and regulate integrin expression via kindlin-2 (Kadry et al., 2018)), Src, Rho, and Ras—that promote tumor progression. The gene discussed is PTK2; the disease is neoplasm.