In prostate cancer, epithelial-mesenchymal transition markers β-catenin, Snail, and E-cadherin do not predict disease free survival (Ipekci et al., 2015); high-grade prostate cancer has reduced E-cadherin expression and some tumors with histologically similar appearance could be distinguished by the presence of mixed populations of E-cadherin negative and E-cadherin positive cells (Umbas et al., 1992). This evidence concerns the gene SNAI1 and Familial prostate cancer.