The presence of E-cadherin would suggest the absence of EMT, however it has been found that carcinoma cells can invade without undergoing traditional EMT, and the tumor cells do not increase mesenchymal markers but do retain cell to cell contact during their invasion—these cells use the mesenchymal characteristics of the CAFs (stromal fibroblasts) to remodel the ECM and consequently follow behind the invading fibroblasts (Gaggioli, 2008). This evidence concerns the gene CDH1 and neoplasm.