However, they also identified phenotypic subsets based, in part, on subcellular localization of E-cadherin—in vivo xenograft tumor growth in SCID nude mice was driven by E/M-MP cells (membrane E-cadherinlow/cytoplasmic E-cadherinhigh/CD133high, CD44high, Tie2low), which produced epithelial ovarian cancer cells (Strauss et al., 2011). This evidence concerns the gene CDH1 and neoplasm.