CDH1 and cancer: Supporting this, Gloushankova et al., determined that a hybrid epithelial-mesenchymal phenotype (a cooperative phenotype) requires the presence of E-cadherin for cancer cell dissemination, buttressing our hypothesis that E-cadherin and E-cadherin-based adherens junctions (AJs) are necessary for collective invasion and tumor migration (Gloushankova et al., 2017).