REST and neoplasm: Furthermore, knockdown of NRSF, which is highly expressed in MB cells, can relieve the inhibitory effect on the gene encoding the de-ubiquitination enzyme USP37, upregulate the expression of USP37 protein and promote the de-ubiquitination of tumor suppressor p27 and stabilize its expression, thus inhibiting the proliferation of tumor cells, which indicates that the classical action of NRSF, namely NRSF-mediated transcription inhibition—especially the NRSF-USP37-P27 pathway—may be a vital regulatory mechanism in the development of MB (Das et al., 2013).