However, in several dementias, such as AD, frontotemporal dementia, and dementia with Lewy bodies, NRSF is almost absent from the nucleus of cortical and hippocampal neurons, while it is found in autophagosomes together with misfolded proteins, thus leading to the upregulation of NRSF-target genes and causing neurodegeneration, which is consistent with the finding that conditional deletion of NRSF from the mouse brain leads to age-related neurodegeneration (Lu et al., 2014). This evidence concerns the gene REST and dementia.