REST and Huntington disease: NRSF represses the transcription process of genes other than BDNF, which may also involve in the pathophysiological process of HD, such as synaptophysin, synaptosomal nerve-associated protein 25, fibroblast growth factor 1, and mitochondrial ornithine aminotransferase, which are responsible for synaptic activity, immunomodulation, neurotransmitter release, the secretion of neurotransmitters, striatal neuronal survival, and glutamate synthesis (Wong et al., 1982; Zuccato et al., 2007; Soldati et al., 2011).