By constructing the network, 19 highly interconnected genes were identified, of which 15 genes (e.g., CD3E, CD69, CD274, KLRD1, PDCD1, LAG3, LILRB4, TNFRSF18, TRAT1, PDCD1LG2, C1QB, GZMK, CXCL13, IDO1, and IRF1) were shown to be correlated with the outcome of CM patients in past reports [30–32], further indicating that our results based on big data mining are valid. This evidence concerns the gene CD69 and cutaneous mastocytosis.