By constructing the network, 19 highly interconnected genes were identified, of which 15 genes (e.g., CD3E, CD69, CD274, KLRD1, PDCD1, LAG3, LILRB4, TNFRSF18, TRAT1, PDCD1LG2, C1QB, GZMK, CXCL13, IDO1, and IRF1) were shown to be correlated with the outcome of CM patients in past reports [30–32], further indicating that our results based on big data mining are valid. Here, KLRD1 is linked to cutaneous mastocytosis.