On contrary, the stages 5-6 of PD are characterized by the up-regulation of the AK1, AK5, nucleoside-diphosphate kinase 5 (NDK5), ecto-5’-nucleotidase (NT5E) and purine nucleoside phosphorylase 1(PNP1) [24]. Here, PTPN13 is linked to Parkinson disease.