Two studies have showed a decreased expression of antiapoptotic Bcl-2 and no changes on proapoptotic protein Bax, indicating an imbalance of Bax/Bcl-2 ratio and consequently, increased Cyt C dissociation and caspase 3 activation after caffeine exposure in GBM cell lines (C6 and U87MG). This evidence concerns the gene CASP3 and glioblastoma.