In conclusion, our results suggested that HB-derived exosomal lncRNA NEAT1 induced MSCs to differentiate into tumor-supporting myofibroblasts by regulating the miR-132/MMP9 axis, which provided a reference and basis for clinical treatment and prognosis judgment of HB in the future and also provided a new target for the treatment of HB. The gene discussed is NEAT1; the disease is neoplasm.