CD274 and hepatocellular carcinoma: Aflatoxin is a risk exposure factor for primary hepatocellular carcinoma, and CRISPR/Cas9 genomic screening identified aryl hydrocarbon receptor as essential for hepatocellular carcinoma (HCC) associated Aflatoxin toxicity, suggesting that an anti-PD-L1 immunosuppression regimen can be used as a treatment regimen for Aflatoxin-associated HCC (111).