CASP8 and neoplasm: As tumor targets, we used the reporter HeLa cell line stably transduced with the NES-ELQTD-GFP-T2A-NES-VGPD-mCherry construct (26), leading to the equimolar expression of two fluorescent reporters: Granzyme B-sensitive nuclear export signal (NES) fused to mCherry and Caspase-8-sensitive NES fused to GFP.