EZH2 and cancer: One key element in organization of the genome are histones and several histone mutations have been discovered that deeply influence transcriptional activity.5 For example, reduction of histone methylation by Lysine to Methionine mutations at specific histones (K-to-M at H3K36, H3F3A, or HIST1H3B) has profound effects on cell growth through transcriptional modifications, a phenomenon conserved in all living systems, from plants6 to eukaryotic cell, including cancer cells.7 Histone mutations alter functioning of effector protein complexes such as PRC2, which includes the methyltransferase EZH2.