Enzymes implicated in cholesterol synthesis have been described as potential targets in adult glioma22 and especially Atorvastatin has been shown to be cytotoxic in A172 human glioma cells.16 A recent publication by a Chinese group did find similar results as ours after treating head and neck squamous cell carcinoma with EZH2. The gene discussed is EZH2; the disease is head and neck squamous cell carcinoma.