CXCR1 and colorectal carcinoma: Xia et al. (2015) proved that high levels of expression of CXCL8 are significantly associated with poor overall survival, tumor stage, lymphatic and liver metastasis. This suggests that CXCL8 could be a potential indicator for both detection and prognosis by meta-analysis. Fisher et al. (2019) demonstrated that blocking the CXCL8-CXCR1 pathway can inhibit the tumorigenicity that originates in the CRC stem cells.