AKR1A1 and lip and oral cavity carcinoma: Genetic polymorphism of the ADH1C gene (ADH1C*1 allele) is associated with various human cancers, such as gastric cancer (Hidaka et al., 2015), oral cancer (Anantharaman et al., 2014) and CRC (Offermans et al., 2018), for it encodes an alcohol dehydrogenase producing 2.5 times more acetaldehyde (Seitz and Stickel, 2010).