Moreover, KEGG analysis using ShinyGO showed that CTHRC1 and its related proteins were predominantly enriched in the signalling pathways of AGE-RAGE, Relaxin and Pl3K-Akt; the pathological processes of small cell lung cancer, amoebiasis and human papillomavirus infection; and the physiological functions of protein digestion and absorption, ECM-receptor interaction, focal adhesion and platelet activation (Figure 8). The gene discussed is RENBP; the disease is human papilloma virus infection.