Over the years, much attention has been given to both AChEandMAO B in the context of dual-target inhibitors for AD treatment, asinferred by the number of X-ray crystallographic structures retrievedwithin the Protein Data Bank (PDB) comprising apo states and binarycomplexes (from different species in the case of AChE) with covalentor reversible inhibitors. This evidence concerns the gene ACHE and Alzheimer disease.