Detection of the mRNA levels of a series of liver fibrosis-related molecules: Acta2, Col1a1, Tgfb1, and Timp1 in livers from IL-21−/−p40−/−IL-2Ra−/− mice and controls suggested no significant change of liver fibrosis (Supplementary Figure 3A). The gene discussed is ACTA2; the disease is Hepatic fibrosis.