The BRCA1 gene has about 2,908 known pathogenic variants (which is greater than the minimum of 0.7) associated with breast-ovarian cancer, familial, susceptibility to, 1, pancreatic cancer, susceptibility to, 4 and Fanconi anemia, complementation group S 20, 21. This evidence concerns the gene BRCA1 and Hereditary breast and ovarian cancer syndrome.