APS-specific autoimmune response is targeting components of the cell membrane i.e., phospholipids (e.g., cardiolipin) and/or their associated proteins (mainly β2-glycoprotein-I [β2GPI]) in its phospholipid-bound “activated” open conformation which is exposing cryptic epitopes in its first domain (4–6). The gene discussed is APOH; the disease is autoimmune polyendocrinopathy.