Another clinical study involving 42 healthy individuals reported that L. johnsonii N6.2 could have beneficial effects on T1DM by regulating the kynurenine:tryptophan ratio, indoleamine 2,3-dioxygenase pathway, circulatory effector Th1 cells, and cytotoxic CD8+ T cells (43). This evidence concerns the gene IDO2 and type 1 diabetes mellitus.