The expression levels of p-ERK1/2, p-p38, and p-JNK were significantly downregulated in the NAFLD+SG group compared with the NAFLD+SHAM group and NAFLD+FR group (Figure 5B), which was secondary to the upregulation of DUSP1 after SG. This evidence concerns the gene MAPK8 and metabolic dysfunction-associated steatotic liver disease.