Moreover, when MYH7-adapted co-segregation-based criteria (PP1_strong; variant segregates with ≥7 meioses, PP1_moderate; variant segregates with ≥5 meioses, or PP1_supportive; variant segregates with ≥3 meioses) is more generally applied to other cardiomyopathy genes, having a variant segregating with disease in only a limited number of family members could already lead to upgrading a variant in a gene with CE but EF < 0.9, or a gene with pLI>0.9 or mis_z > 3.0 to an LP status. This evidence concerns the gene MYH7 and cardiomyopathy.