CD276 and neoplasm: In addition, CD276 is highly expressed in head and neck squamous cell carcinoma and the blockade of CD276 significantly inhibited the lymph node metastasis of head and neck squamous cell carcinoma, which is one of the most challenging problems in the treatment of head and neck squamous cell carcinoma, indicating that targeting CD276 can enhance anti-tumor immunity (Wang et al., 2021).