Among them, AC099850.3 is the most co-expressed lncRNA, which is related to six differently expressed mRNAs, namely (CAV1, NRAS, ACSL3, AURKA, EIF2AK4 and RRM2), and its high expression level is closely related to the reduction in the survival rate of patients with tongue cancer (Zhou et al., 2019). The gene discussed is RRM2; the disease is tongue cancer.