According to a recent study outlining a comprehensive PD gene database (GENE4PD), a functional correlation network was simulated between “high confidence” and “suggestive” PD-associated genes in PD pathways resulting in significant associations, including those seen with RIC3 and CHCHD2, with the latter significantly linked to SNCA, PINK1, LRRK2, PARK7, and VPS35 - a likely potential for expanding our knowledge on PD pathway architecture and future annotations (Li B et al., 2021). This evidence concerns the gene VPS35 and Parkinson disease.