For example, miR-193b binds to the 3′ UTR of Amyloid Precursor Protein (APP) mRNA and represses its ensuing protein expression; interestingly, this miRNA also maintains significantly lower exosomal concentrations among AD patients, suggesting its low levels may exacerbate the generation of Aβ (Liu et al., 2014; Yang et al., 2018). Here, APP is linked to Alzheimer disease.