To determine whether apoE has isoform-dependent effects on hAPP/Aβ-induced behavioral alterations and cognitive impairments in adult female and male mice at 6 months of age, we crossed APP NL-G-F mice with E2, E3, and E4 mice to generate NL-G-F/E2, NL-G-F/E3, and NL-G-F/E4 mice. The gene discussed is APP; the disease is Cognitive impairment.