It is reported that the ethanol extracts of Gleditsiae Spina can maintain tumor cells proliferation in G2/M phase, regulate phosphorylation of extracellular signal-regulated kinases (ERK), tumor necrosis factor-alpha (TNF-α), matrix metalloproteinase-9 (MMP-9) expression, and to inhibit tumor cell growth [16]. Here, MMP9 is linked to neoplasm.