NPPB and diabetic kidney disease: In summary, these results indicate that GLP produces a significant protective effect in diabetic nephropathy by reducing the renal pathological damage and decreasing blood glucose and glycated hemoglobin and improves the kidney function indicated by decreasing the levels of serum creatinine, blood urea nitrogen, and 24 h urine protein as well as the renal α-SMA and BNP expressions and even more GLP increased body weight and kidney weight.