ACTA1 and renal fibrosis: Meroterpenoids from Ganoderma cochlear, cochlearols A and B and polycyclic meroterpenoids, exerted renoprotectivity by inhibiting the expression of renal fibrosis related markers such as collagen I, fibronectin, and α-SMA in a dose-dependent manner (5, 10, and 20 μM) [31].