Although IL20RB was initially found to be involved in many nonmalignant diseases, such as psoriasis [16], rheumatoid arthritis [17], vitiligo [18], ulcerative colitis [19], glaucoma [20], asthma [21], endometriosis [22], and chronic rhinosinusitis [23] as well as infectious diseases [24], novel discoveries indicate IL20RB could also play an important role in malignant diseases. The gene discussed is IL20RB; the disease is chronic rhinosinusitis.