CD8A and colitis: Interestingly, as shown in Figure 4, although AOAA treatment further increased the percentage of T cells and CD4+ T cells in colitis mice compared with the DSS+PBS group (Figures 4(d) and 4(e)), it declined 47% of macrophages (P < 0.001) (Figure 4(a)), 41% of monocytes (P < 0.01) (Figure 4(b)), 26% of neutrophils (P < 0.01) (Figure 4(c)), and 20% of CD8+ T cells (P < 0.05) (Figure 4(f)), respectively, suggesting that the local immune environment of the colon was improved and the difference of macrophages was the most significant.