Tumor cells in ALCL were large with higher forward scatter (FSC)/SSC and revealed variable loss of pan-T-cell markers (i.e., CD2, CD3, CD5, CD7, and CD4 restriction) and co-expressions of CD25 and CD26 but were negative for CD10, CD16, CD56, CD57, CD185 (CXCR5), CD279 (PD1), TCL1, and TCRγδ expressions. This evidence concerns the gene CXCR5 and anaplastic large cell lymphoma.