Tumor cells in ALCL were large with higher forward scatter (FSC)/SSC and revealed variable loss of pan-T-cell markers (i.e., CD2, CD3, CD5, CD7, and CD4 restriction) and co-expressions of CD25 and CD26 but were negative for CD10, CD16, CD56, CD57, CD185 (CXCR5), CD279 (PD1), TCL1, and TCRγδ expressions. The gene discussed is CD4; the disease is anaplastic large cell lymphoma.