Abnormal lymphocytes in cutaneous T-cell lymphoma [CTCL; including mycosis fungoides (MF)] were characterized by CD4 restriction, variable loss of CD7 and CD26, moderate CD2, moderate-to-dim surface CD3 and CD5, and heterogeneous CD279 (PD1) but negative expressions of CD8, CD10, CD16, CD56, CD57, CD185 (CXCR5), and TCRγδ. This evidence concerns the gene CD4 and primary cutaneous T-cell non-Hodgkin lymphoma.