RAI2 and colorectal carcinoma: In this study, we further detected the expression of RAI2 in 298 cases of CRC tissue samples by IHC, and found that low expression (score ≤3, 101/298) of RAI2 was significantly associated with reduced phosphorylation of β-catenin (r=0.8866, P<0.0001), poor 5-year OS (P = 0.0102), and 5-year RFS (P = 0.0029) (Figures 4A, B).