We gain similar results in L-OHP-treated cells, the IC50 of L-OHP was 7.90 ± 2.21μM versus 3.27 ± 0.37μM in LoVo cells with empty vetor and RAI2 transfected (P=0.0233), and 4.52 ± 1.25 μM versus 2.09 ± 0.56 μM (P=0.0373) in HCT116 cells with empty vetor and RAI2 transfected, while no significant difference was found in RAI2-M-transfected CRC cells controlled with vector group in both LoVo and HCT116 cells (P>0.05) (Figure 5F). Here, RAI2 is linked to colorectal carcinoma.