APC and colorectal carcinoma: It revealed that the inhibition of Wnt signaling by RAI2 in CRC with mutant APC may through destruction of interaction between CtBP2 and mutant APC, while in CRC with wild-type APC, the inhibition of Wnt signaling by RAI2 may involve a different mechanism, such as transcriptional down-regulation of CtBP2, an indirect approach.