In addition, by searching The Cancer Genome Atlas (TCGA) (http://xena.ucsc.edu/) databases and analyzing RNA sequencing (RNA-Seq) data in 434 cases of CRC samples, we found that the expression of CtBP2 was negatively correlated with the expression of RAI2 (p<0.0001) (Figure 1B). Here, CTBP2 is linked to colorectal carcinoma.