For RYR3, the top five signaling pathways in the positive correlative group were ‘autoimmune thyroid disease’, ‘ECM receptor interaction’, ‘nicotinate and nicotinamide metabolism’, ‘primary immunodeficiency’, and ‘starch and sucrose metabolism’ (Figure 6A); whereas the most significant signalling pathways in the negative correlative group were ‘ribosome’, ‘RNA degradation’, and ‘spliceosome’ (Figure 6B). The gene discussed is RYR3; the disease is autoimmune thyroid disease.