Other mechanisms of angiogenesis regulation acting via cancer cells were reported in mouse models of melanoma and myxoid liposarcoma, where trabectedin stimulated the tumoral expression of thrombospondin-1 (TSP-1), a major endogenous inhibitor of angiogenesis or of TIMP‐1 (31, 44). This evidence concerns the gene THBS1 and myxoid liposarcoma.