EOMES and neoplasm: investigated the effects of trabectedin on tumor-infiltrating leukocytes in a genetic model of pancreatic cancer, a highly immunosuppressive tumor; treatment with trabectedin significantly reduced the immunosuppression in the TME: T lymphocytes sorted from treated tumors, showed an increased percentage of IFNγ+ Eomes+ and PD-1+ T cells, compared to untreated tumors, that were characterized by a higher proportion of IL10-expressing T cells.