Immunoblotting demonstrated that Caspase-1 activation levels, measured by detection of the cleavage of pro-Caspase-1 (p45) to its mature form (p20 subunit), were comparable between either gastric tumor or non-tumor tissues from gp130F/F:Nlrp3-/- and gp130F/F mice (Figures 4A, B). The gene discussed is NLRP3; the disease is gastric neoplasm.