While our current study suggests otherwise, these contrasting disease associations for NLRP3 in GC, as is commonplace for many other PRRs in cancers, are most likely explained by the high genetic and molecular heterogenicity in human GC, together with differences in study design relating to patient characteristics (e.g., geographical location, ethnicity, age, tumor stage, histological grade, and anatomical location). Here, NLRP3 is linked to cancer.