NLRP3 and gastric neoplasm: In support of these gene expression data, immunohistochemistry indicated that the total number of NLRP3 positively stained cells was significantly greater in gp130F/F antral tumors compared to normal antral tissue from WT mice, with predominant staining observed in the gastric tumor epithelium of gp130F/F mice (Figures 2B, C).