Although the role of NLRP3 in GC has been poorly investigated to date, it is worth comparing our findings with a recent study using human cell lines, in which it was suggested that the NLRP3 inflammasome (via IL-1β) promoted GC cell proliferation and tumorigenesis by upregulating transcription of the cell cycle regulatory gene, CCND1 (41). This evidence concerns the gene CCND1 and gastric cancer.