NLRP3 and neoplasm: Furthermore, immunohistochemical staining on a third cohort (Australian) of GC patients (16, 17) indicated that NLRP3 protein expression levels were elevated in patient tumors compared to matched non-tumor gastric tissues, with increased numbers of diffusely stained NLRP3-positive cells observed throughout the transformed glandular epithelium and in immune cells in the stroma of patient tumor tissues (Figures 1G–I).