Mutational profiles subdivided meningiomas into genetically distinct subgroups most of which had either a single oncogenic driver mutation or previously described co-mutations such as KLF4 K409Q (K443Q) with an altered TRAF7 or AKT1 E17K with an altered TRAF7 (Figure 3A and Supplementary Table 3). Here, KLF4 is linked to meningioma.