Subsequently, it was found that IL-10 is secreted by a variety of cells and has multiple effects on T and Blymphocytes, bone marrow cells, etc. In 2009, mutation of IL-10RA-IL-10RB was found in infants with IBD, providing a new comprehension of the pathogenesis of IBD (23), which is consistent with the conclusion of previous studies that the lack of an anti-inflammatory effect of IL-10 causes the activation of an explosive intestinal immune response. This evidence concerns the gene IL10RB and inflammatory bowel disease.