PBMC of MS patients showed increased production of IFN-α, IL-6, and IL-10 but decreased production of IL-4 (Sanna et al., 2008) and productions of IL-6 and IL-10 by PBMC and plasmacytoid DC were lower in MS patients compared with healthy controls (Sanna et al., 2008). Here, IL4 is linked to myeloid sarcoma.