An increasing number of preclinical studies suggest that prolonged exposure to general anesthesia can induce delirium‐like behavior, including cognitive impairment, as well as molecular and cellular changes characteristic of neurodegeneration such as endoplasmic reticulum (ER) stress, tau hyperphosphorylation, neuroinflammation, and cell death (Vutskits & Xie, 2016). The gene discussed is MAPT; the disease is Cognitive impairment.