Nek1-deficient mice develop facial dysmorphism, male sterility, and slowly progressing polycystic kidney disease (PKD), with renal pathology similar to that of human autosomal dominant polycystic kidney disease (ADPKD), because Nek1 functions in the formation of primary cilia [45, 46]. This evidence concerns the gene NEK1 and autosomal dominant polycystic kidney disease.