PDCD1 and neoplasm: Based on the preliminary antitumor activity of cetrelimab in patients with advanced solid tumors in LUC1001 [52], studies are ongoing to evaluate the safety and efficacy of cetrelimab in combination with intravesical gemcitabine (TAR-200; JNJ-17000139-AAC) in non-muscle-invasive bladder cancer (NCT04640623) and in combination with erdafitinib in patients with urothelial carcinoma carrying FGFR alterations (NCT03473743), as chemotherapy or targeted therapy can release tumor neoantigens and prime the tumor microenvironment for immune response by a PD-1 inhibitor.