Furthermore, it has been shown that digoxin application has an inhibitory effect on the HIF1 signaling pathway,74,88,89 and can inhibit tumor growth by inducing cell-cycle arrest and apoptosis.89-91 Our scRNA-Seq data also indicate an involvement of the HIF1 pathway, adding hypoxic conditions as a possible reason for cell death upon digoxin application. Here, HIF1A is linked to neoplasm.