SYK and retinoblastoma: In 2018, moxifloxacin, a broad-spectrum antibiotic, was tested on retinal organoids, indicating that, similar to adult mouse retina, the primary affected cell types were photoreceptors.6 Additionally, Saengwimol and colleagues12 used a retinoblastoma retinal organoid model to assess the effect of well-known chemotherapy drugs, and recently, Liu et al.13 also tested the effect of spleen tyrosinase kinase (SYK) inhibitors on a retinoblastoma organoid model, displaying a significant therapeutic response.