NLRP3 and familial Mediterranean fever: To overcome this limitation, NGS can be applied to sequence gene panels including not only MEFV for the diagnosis of FMF but also genes which are associated with other periodic fever syndromes like mevalonate kinase deficiency (MKD, gene MVK), tumor necrosis factor receptor-associated periodic syndrome (TRAPS, gene TNFRSF1A) and cryopyrin-associated periodic syndrome (CAPS, gene NLRP3) [26,27].