YWHAQ and obesity due to melanocortin 4 receptor deficiency: To examine whether inhibition of 14-3-3 proteins could have similar effects in the context of obesity but without overt diabetes, islets from 9-week-old obese ob/ob and nonobese ob/+ control mice (Supplemental Figure 6, A and B) were isolated and exposed to 14-3-3 protein inhibitors.