S1PR1 and diabetes mellitus: Notwithstanding, systemic inhibition of 14-3-3 proteins with FTY720 (Fingolimod), which was initially identified as a sphingosine-1-phosphate receptor agonist (59), has already been shown to ameliorate diabetes in models of type 1 and type 2 diabetes, and this highlights the potential of targeting 14-3-3 proteins.