Cell type–dependent effects on cell survival have been observed following the overexpression or depletion of various 14-3-3 proteins (22, 36, 37), and while we previously reported that 14-3-3 protein inhibition or siRNA-mediated knockdown of 14-3-3 isoforms induced apoptosis in MIN6 insulinoma cells (14), incubation of mouse islet cells with 14-3-3i or BV02 for 72 hours did not have detrimental effects on cell viability (Figure 1I). This evidence concerns the gene YWHAQ and pancreatic insulinoma.